Biofield Treatment: A Potential Strategy for Modification of Physical and Thermal Properties of Indole

Indole compounds are important class of therapeutic molecules, which have excellent pharmaceutical applications. The objective of present research was to investigate the influence of biofield treatment on physical and thermal properties of indole. The study was performed in two groups (control and treated). The control group remained as untreated, and biofield treatment was given to treated group. The control and treated samples were characterized by X-ray diffraction (XRD), differential scanning calorimetry (DSC), thermogravimetric analysis (TGA), Fourier transform infrared (FT-IR) spectroscopy and ultraviolet-visible (UV-Vis) spectroscopy. XRD study demonstrated the increase in crystalline nature of treated indole as compared to control. Additionally, the treated indole showed increase in crystallite size by 2.53% as compared to control. DSC analysis of treated indole (54.45ºC) showed no significant change in melting temperature (Tm) in comparison with control sample (54.76ºC). A significant increase in latent heat of fusion (?H) by 30.86% was observed in treated indole with respect to control. Derivative thermogravimetry (DTG) of treated indole showed elevation in maximum thermal decomposition temperature (Tmax) 166.49ºC as compared to control (163.37ºC). This was due to increase in thermal stability of indole after biofield treatment. FT-IR analysis of treated indole showed increase in frequency of N-H stretching vibrational peak by 6 cm-1 as compared to control sample. UV spectroscopy analysis showed no alteration in absorption wavelength (?max) of treated indole with respect to control. The present study showed that biofield has substantially affected the physical and thermal nature of indole.

The study results showed the significant impact of biofield treatment on physical and thermal properties of indole. XRD data on treated indole showed an increase in crystallite size with respect to control sample. It is presumed that decrease in nuclear density may cause increase in crystallite size. DSC analysis of treated indole showed no change in melting temperature as compared to control. Additionally, latent heat of fusion was substantially increased by 30.86% in treated indole as compared to control. TGA analysis of treated indole showed enhanced thermal stability as compared to control sample. FTIR data showed increase in force constant and stability of the N-H bond of treated indole as compared to control. The enhanced crystallite size and high thermal stability of treated indole may improve the reaction rate. Hence, it is assumed that biofield treated indole could be used as intermediate for synthesis of pharmaceutical compounds.