Published: December 26, 2018 Volume: 5 Issue: 2 Pages: 92-98
DOI: 10.15436/2377-1313.18.2041 ISSN: 2377-1313
Authors: Alice Branton , Mahendra Kumar Trivedi, Dahryn Trivedi, Gopal Nayak, Snehasis Jana
Citation: Branton, A., et al. Evaluation of the Physicochemical and Thermal Properties of Sulfamethoxazole: Influence of the Energy of Consciousness Healing Treatment (2018) J pharma pharmaceutics 5(2): 92- 98.
Abstract
Sulfamethoxazole is a broad spectrum antibiotic that acts as a bacteriostatic antibacterial agent. This study was aimed to analyze the effect of Consciousness Energy Healing Treatment (the Trivedi Effect®) on the physicochemical and thermal properties of sulfamethoxazole with the help of advanced analytical techniques. Sulfamethoxazole sample was divided into two parts. Among these, one part received Consciousness Energy Healing Treatment remotely by a well-known Biofield Energy Healer, Alice Branton and termed as the treated sample. While the other part did not receive the Consciousness Energy Healing Treatment called a control sample. The study revealed that the particle size values in the treated sample were significantly reduced by 19.71% (d10), 6.28 % (d50), 5.40 % (d90), and 7.98 % {D (4, 3)}; thus, the specific surface area was significantly increased by 12.63% compared with the untreated sample. The powder XRD peak intensities and crystallite sizes were altered significantly ranging from -32.49% to 120.17% and 0.45% to 101.86%, respectively; whereas, the average crystallite size was significantly increased by 33.13% in the treated sample compared with the control sample. The TGA data reported 8.35% increase in total weight loss and 19.55% significant reduction of the residual amount in the treated sample compared with the control sample. The latent heat of fusion was significantly increased by 10.34% and the degradation temperature along with the corresponding latent heat of decomposition of the treated sample was increased by 5.52% and 11.16%, respectively compared with the untreated sample. The Trivedi Effect®-Consciousness Energy Healing Treatment might have created a new polymorphic form of sulfamethoxazole which would be better soluble and bioavailable compared with the untreated sample. The Trivedi Effect Treated sulfamethoxazole might be more beneficial for designing more efficacious novel nutraceutical / pharmaceutical formulations for the prevention and treatment of various diseases such as urinary tract infections, ear infections
Conclusion
The study shows that the Trivedi Effect®-Consciousness Energy Healing Treatment imparts significantly on the particle size, surface area, peak intensities, crystallite size, and thermal properties of the sulfamethoxazole powder. The particle size values in the Biofield Energy Treated sample were observed to be significantly decreased by 19.71%, 6.28%, 5.40%, and 7.98% at d10, d50, d90, and D (4,3), respectively compared to the control sample. Moreover, the specific surface area of the Biofield Energy Treated sample was significantly increased by 12.63 % compared with the untreated sample. Such alterations in the particle size may improve the dissolution and absorption parameters of the treated sample compared to the untreated sulfamethoxazole. The PXRD data showed sharp and intense peaks in the diffractograms of both the samples, thereby indicating their crystalline nature. Later on, the peak intensities of the Biofield Energy Treated sample were observed to be significantly altered in the range of -32.49% to 120.17% compared to the control sample. Also, the treated sample showed an increase in the crystallite sizes along these characteristic peaks in the range from 0.45% to 101.86% compared to the untreated sample. Overall, the average crystallite size of the Biofield Energy Treated sulfamethoxazole sample was found to be significantly increased by 33.13% compared with the control sample. The TGA study represented that the total weight loss of the Biofield Energy Treated sample was significantly increased by 12.27%; however, the residual amount was reduced by 19.54% in comparison with the control sulfamethoxazole sample. Besides, the ?Hfusion was increased by 10.34% in the treated sample compared to the control sample. Also, the degradation temperature as well as the corresponding ?Hdecomposition of the treated sample was observed to be increased by 5.52% and 11.16%, respectively, compared to the untreated sample. The overall results concluded that the Trivedi Effect® might create a new polymorphic form of sulfamethoxazole that might show better.
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